Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13604352 | 0.88 | MEN1 (0.55) | RAB9APOLBNR4A1PARP1ALDH1A1 | |
| SCHEMBL4484577 | 0.81 | SIRT2 (0.48) | — | |
| SCHEMBL13604570 | 0.77 | SIRT2 (0.41) | PARP1SMN1; SMN2 | |
| SCHEMBL9410518 | 0.74 | MAPT (0.69) | RAB9APOLBNR4A1MAPK1HPGD | |
| SCHEMBL3815593 | 0.72 | RAB9A (0.65) | RAB9APOLBNR4A1MAPK1HPGD | |
| SCHEMBL4477317 | 0.72 | CYP11B1 (0.55) | — | |
| SCHEMBL25583831 | 0.72 | CYP11B1 (0.55) | RAB9AL3MBTL1ALDH1A1NPC1KMT2A | |
| SCHEMBL6528673 | 0.72 | PHF8 (0.57) | POLBHPGDL3MBTL1GAAALDH1A1 | |
| SCHEMBL10970617 | 0.72 | RAB9A (0.85) | RAB9APOLBNR4A1MAPK1L3MBTL1 | |
| SCHEMBL24690443 | 0.71 | POLB (0.63) | RAB9APOLBNR4A1MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635697-B2 | Farnesyl protein transferase inhibitors and methods for treating proliferative diseases | SCHERING CORPORATION (US) | 2009-12-22 | — | — | US | disclosed |