Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24845648 | 0.84 | CYP11B1 (0.58) | PHF8CYP11B1CYP11B2KDM4CHTT | |
| SCHEMBL1196872 | 0.83 | HPGDS (0.51) | PHF8CYP11B1CYP11B2KDM4CNPC1 | |
| Ethane SCHEMBL29134244 | 0.82 | HPGDS (0.50) | PHF8CYP11B1CYP11B2KDM4CNPC1 | |
| SCHEMBL6531587 | 0.82 | PHF8 (0.51) | PHF8CYP11B1CYP11B2KDM4CHTT | |
| SCHEMBL6528669 | 0.81 | CYP11B1 (0.55) | PHF8CYP11B1CYP11B2KDM4CHTT | |
| SCHEMBL25583831 | 0.81 | CYP11B1 (0.55) | CYP11B1CYP11B2KDM4CSMN1; SMN2NPC1 | |
| SCHEMBL18961310 | 0.81 | CYP11B1 (0.55) | PHF8CYP11B1CYP11B2KDM4CHTT | |
| SCHEMBL24845150 | 0.81 | CYP11B1 (0.55) | PHF8CYP11B1CYP11B2KDM4CHTT | |
| SCHEMBL4477317 | 0.81 | CYP11B1 (0.55) | PHF8CYP11B1CYP11B2 | |
| SCHEMBL6528482 | 0.79 | LPO (0.52) | LMNAALDH1A1SIGMAR1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |