Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21959622 | 0.81 | NOS3 (0.32) | RAB9A | |
| SCHEMBL13228074 | 0.73 | PSMB5 (0.41) | PSMB5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL17265838 | 0.73 | DYRK1A (0.34) | — | |
| SCHEMBL13311450 | 0.71 | MEN1 (0.42) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL16390153 | 0.70 | PSMB5 (0.47) | PSMB5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL14488757 | 0.70 | PSMB5 (0.44) | PSMB5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13486512 | 0.69 | HTR3A (0.36) | MEN1KMT2A | |
| SCHEMBL21958567 | 0.68 | MEN1 (0.30) | MEN1KMT2A | |
| SCHEMBL13712730 | 0.68 | PSMB5 (0.40) | PSMB5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL19337377 | 0.68 | PARP1 (0.30) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7638530-B2 | 1-{1-[4-(3-amino-5-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one; anticarcinogenic agents | MERCK & CO., INC. (US) | 2009-12-29 | — | — | US | disclosed |