Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 4/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | NGFR | P08138 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9885160 | 0.89 | GSK3B (0.42) | PARP1KIF11PDGFRBKDRIDO1 | |
| SCHEMBL3209490 | 0.85 | AAK1 (0.46) | PARP1KIF11PDGFRBKDRCA12 | |
| SCHEMBL1548083 | 0.85 | PARP10 (0.43) | KIF11MAPTMITFCYP3A4KDM4E | |
| SCHEMBL3215660 | 0.85 | IKBKB (0.36) | KIF11PDGFRBKDRMAPTMITF | |
| SCHEMBL1547761 | 0.85 | KDM4E (0.41) | KIF11CDK5CDK5R1KDM4EALDH1A1 | |
| SCHEMBL3206966 | 0.84 | MEN1 (0.42) | PARP1LIN28ACA12CA9CYP3A4 | |
| SCHEMBL3216680 | 0.84 | DYRK1A (0.40) | KIF11 | |
| SCHEMBL3212685 | 0.84 | TDO2 (0.47) | KIF11IDO1TDO2KDM4EALDH1A1 | |
| SCHEMBL3205976 | 0.84 | MAPT (0.50) | KIF11PDGFRBKDRMAPTMITF | |
| SCHEMBL3197147 | 0.82 | PARP1 (0.44) | PARP1KIF11KDRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119703-A1 | NOVEL INDOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON I B KINASE | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-18 | — | — | EP | disclosed |