Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | F13A1 | P00488 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15045551 | 0.90 | GPR17 (0.46) | PARP10CHEK2BTKALDH1A1KMT2A | |
| SCHEMBL1548067 | 0.89 | CHEK2 (0.41) | CHEK2KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL12651132 | 0.87 | GPR17 (0.34) | PARP10CHEK2ALDH1A1GAAMAPT | |
| SCHEMBL1548315 | 0.86 | ALDH1A1 (0.51) | ALDH1A1MAPTHPGDKMT2AMEN1 | |
| SCHEMBL13613410 | 0.85 | PARP1 (0.41) | BTKALDH1A1GAAMAPTKDM4E | |
| SCHEMBL1548263 | 0.85 | MEN1 (0.45) | CHEK2BTKALDH1A1MAPTKDM4E | |
| SCHEMBL9885160 | 0.83 | GSK3B (0.42) | HDAC1KIF11 | |
| SCHEMBL1547971 | 0.83 | KDM4E (0.51) | ALDH1A1GAAMAPTKDM4EHPGD | |
| SCHEMBL1548405 | 0.82 | MEN1 (0.38) | ALDH1A1GAAMAPTKDM4EHPGD | |
| SCHEMBL1548446 | 0.82 | GRM5 (0.36) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2314575-B1 | NOVEL INDOLE DERIVATIVE HAVING CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP | SANTEN PHARMACEUTICAL CO LTD (JP) | 2013-06-19 | — | — | EP | disclosed |
| EP-2314575-B1 | NOVEL INDOLE DERIVATIVE HAVING CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP | SANTEN PHARMACEUTICAL CO LTD (JP) | 2013-06-19 | — | — | EP | disclosed |
| US-8445529-B2 | Indole derivative having, carbamoyl group, ureido group and substituted oxy group | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2013-05-21 | — | — | US | disclosed |
| US-8445529-B2 | Indole derivative having, carbamoyl group, ureido group and substituted oxy group | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2013-05-21 | — | — | US | disclosed |
| US-20110124668-A1 | NOVEL INDOLE DERIVATIVE HAVING, CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2011-05-26 | — | — | US | disclosed |
| US-20110124668-A1 | NOVEL INDOLE DERIVATIVE HAVING, CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2011-05-26 | — | — | US | disclosed |
| EP-2314575-A1 | NOVEL INDOLE DERIVATIVE HAVING CARBAMOYL GROUP, UREIDE GROUP AND SUBSTITUTED OXY GROUP | Santen Pharmaceutical Co., Ltd (JP) | 2011-04-27 | — | — | EP | disclosed |
| EP-2314575-A1 | NOVEL INDOLE DERIVATIVE HAVING CARBAMOYL GROUP, UREIDE GROUP AND SUBSTITUTED OXY GROUP | Santen Pharmaceutical Co., Ltd (JP) | 2011-04-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124668-A1 | NOVEL INDOLE DERIVATIVE HAVING, CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP | IKBKB, CHUK, RELA | PARP10 1479/4885CHEK2 923/4885BTK 662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.