Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.50 |
| ▸ | JAK1 | P23458 | 7/20 | 0.50 |
| ▸ | TYK2 | P29597 | 7/20 | 0.50 |
| ▸ | JAK3 | P52333 | 6/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.38 |
| ▸ | PTP4A2 | Q12974 | 1/20 | 0.38 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3826251 | 0.75 | DYRK1A (0.56) | JAK2JAK3PDPK1MAP2K1ADORA2A | |
| SCHEMBL5774666 | 0.71 | JAK2 (0.54) | JAK2JAK1TYK2JAK3MAP3K8 | |
| SCHEMBL5469860 | 0.70 | JAK2 (0.73) | JAK2JAK1TYK2JAK3MAP3K8 | |
| SCHEMBL13606545 | 0.70 | JAK2 (0.56) | JAK2JAK1TYK2JAK3MAP3K8 | |
| SCHEMBL5550318 | 0.69 | MAP3K8 (0.53) | JAK2JAK1TYK2JAK3MAP3K8 | |
| SCHEMBL4509363 | 0.69 | JAK2 (0.76) | JAK2JAK1TYK2JAK3MAP3K8 | |
| SCHEMBL13606542 | 0.69 | JAK2 (0.58) | JAK2JAK1TYK2JAK3MAP3K8 | |
| SCHEMBL20609434 | 0.67 | PDPK1 (0.56) | PDPK1ADORA2AADORA1CYP2A6KDR | |
| SCHEMBL14447663 | 0.67 | JAK2 (1.00) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL2175845 | 0.66 | PDPK1 (0.70) | PDPK1ADORA2AADORA1CYP2A6KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635695-B2 | Antiinflammation agents | AMGEN INC. (US) | 2009-12-22 | — | — | US | disclosed |
| US-20070155777-A1 | Antiinflammation agents | AMGEN, INC. | 2007-07-05 | — | — | US | disclosed |
| US-20070155777-A1 | Antiinflammation agents | AMGEN, INC. | 2007-07-05 | — | — | US | disclosed |
| US-7199119-B2 | Antiinflammation agents | AMGEN INC. (US) | 2007-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155777-A1 | Antiinflammation agents | TNF, NFATC1, NFKBIA | JAK2 1101/4885JAK1 1726/4885TYK2 2825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.