Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.54 |
| ▸ | JAK1 | P23458 | 12/20 | 0.54 |
| ▸ | TYK2 | P29597 | 12/20 | 0.54 |
| ▸ | JAK3 | P52333 | 11/20 | 0.54 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.41 |
| ▸ | PTP4A2 | Q12974 | 1/20 | 0.41 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.41 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777178 | 0.85 | JAK2 (0.38) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL5469860 | 0.74 | JAK2 (0.73) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL13606545 | 0.74 | JAK2 (0.56) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL13606542 | 0.73 | JAK2 (0.58) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL4509363 | 0.73 | JAK2 (0.76) | JAK2JAK1TYK2JAK3MAP3K8 | |
| SCHEMBL13613569 | 0.71 | JAK2 (0.50) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL14447663 | 0.70 | JAK2 (1.00) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL4501679 | 0.68 | JAK2 (0.62) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL15574621 | 0.67 | MAPT (0.40) | IKBKBPTP4A3PTP4A2PTP4A1RAB9A | |
| SCHEMBL5746080 | 0.67 | MAPT (0.49) | IKBKBPTP4A3PTP4A2PTP4A1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556053-A4 | ANTIINFLAMMATION AGENTS | AMGEN INC (US) | 2006-04-19 | — | — | EP | disclosed |
| EP-1556053-A1 | ANTIINFLAMMATION AGENTS | Amgen Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004041285-A1 | ANTIINFLAMMATION AGENTS | AMGEN INC. (US) | 2004-05-21 | — | — | WO | disclosed |