Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27904957 | 0.78 | BTK (0.59) | DYRK1A | |
| SCHEMBL5550688 | 0.75 | BRAF (0.49) | MAP3K8MAPK1MAP2K1BRAF | |
| SCHEMBL5553871 | 0.75 | MAP3K8 (0.86) | MAP3K8MAPK1MAP2K1DYRK1AMAP4K4 | |
| SCHEMBL17165803 | 0.75 | DYRK1A (0.53) | MAP2K1DYRK1AMAP4K4JAK2JAK3 | |
| SCHEMBL3826251 | 0.71 | DYRK1A (0.56) | MAP2K1DYRK1AMAP4K4ADORA2AJAK2 | |
| SCHEMBL5553863 | 0.70 | MAP3K8 (0.44) | MAP3K8MAPK1MAP2K1ADORA2ALIMK1 | |
| SCHEMBL13613569 | 0.69 | JAK2 (0.50) | MAP3K8MAPK1MAP2K1ADORA2AJAK2 | |
| SCHEMBL27631899 | 0.69 | DHFR (0.69) | MAP3K8MAPK1MAP2K1ADORA2AADORA1 | |
| SCHEMBL5555013 | 0.69 | MAP3K8 (0.57) | MAP3K8MAPK1MAP2K1DYRK1AJAK3 | |
| SCHEMBL15089131 | 0.67 | MAP4K4 (0.47) | MAP3K8MAP4K4ADORA2AUSP7LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753428-A2 | KINASE INHIBITORS AS THERAPEUTIC AGENTS | Abbott Laboratories (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20060074102-A1 | Kinase inhibitors as therapeutic agents | ABBOTT LABORATORIES | 2006-04-06 | — | — | US | disclosed |
| WO-2005110410-A2 | KINASE INHIBITORS AS THERAPEUTIC AGENTS | ABBOTT LABORATORIES (US) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060074102-A1 | Kinase inhibitors as therapeutic agents | ABL1, MAP3K19, MAP3K20 | MAP3K8 13/4885MAPK1 39/4885MAP2K1 216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.