Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.57 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | USP1 | O94782 | 1/20 | 0.45 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6896030 | 0.85 | ADRB1 (0.56) | ADRB1ADRB2ADRB3HTTLMNA | |
| SCHEMBL16781355 | 0.83 | LMNA (0.53) | ADRB1ADRB2ADRB3HTTLMNA | |
| SCHEMBL13428831 | 0.82 | LMNA (0.49) | ADRB1ADRB2ADRB3HTTLMNA | |
| SCHEMBL13614231 | 0.81 | CYP3A4 (0.52) | ADRB1ADRB2ADRB3HTTLMNA | |
| SCHEMBL1311776 | 0.80 | LMNA (0.53) | ADRB1ADRB2ADRB3HTTLMNA | |
| SCHEMBL10130598 | 0.80 | LMNA (0.53) | HTTLMNAMAPTENPP2MKNK1 | |
| SCHEMBL20852025 | 0.78 | CYP3A4 (0.50) | ADRB1ADRB2ADRB3HTTLMNA | |
| SCHEMBL255498 | 0.77 | MAOB (0.62) | HTTLMNAMAPTENPP2MKNK1 | |
| SCHEMBL1846405 | 0.76 | MAPT (0.55) | ADRB1ADRB2ADRB3HTTLMNA | |
| SCHEMBL2513928 | 0.75 | HTT (0.57) | ADRB1ADRB2ADRB3HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432700-B1 | SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-04 | — | — | EP | disclosed |