Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 8/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP2 | P42575 | 1/20 | 0.48 |
| ▸ | CASP4 | P49662 | 1/20 | 0.48 |
| ▸ | CASP5 | P51878 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2538476 | 0.83 | LMNA (0.54) | KMT2AKDM4EPOLBALDH1A1HSD17B10 | |
| SCHEMBL12225750 | 0.83 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1HSD17B10CASP6 | |
| SCHEMBL3922786 | 0.83 | LMNA (0.62) | MEN1KMT2AALDH1A1GAATSHR | |
| SCHEMBL10979724 | 0.83 | ALDH1A1 (0.49) | MEN1KMT2AKDM4EPOLBALDH1A1 | |
| SCHEMBL2825786 | 0.82 | ALDH1A1 (0.62) | MEN1KMT2AKDM4EPOLBALDH1A1 | |
| SCHEMBL23752224 | 0.82 | MEN1 (0.55) | MEN1KMT2AKDM4EPOLBALDH1A1 | |
| SCHEMBL3760477 | 0.81 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1HSD17B10LMNA | |
| SCHEMBL11460936 | 0.81 | MAPK1 (0.69) | MEN1KMT2AALDH1A1TSHRLMNA | |
| SCHEMBL15880673 | 0.80 | ALDH1A1 (0.64) | MEN1KMT2AKDM4EPOLBALDH1A1 | |
| SCHEMBL2836625 | 0.79 | ALDH1A1 (0.62) | MEN1KMT2AKDM4EPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432700-B1 | SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-04 | — | — | EP | disclosed |