Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 8/20 | 0.70 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | STAT1 | P42224 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.55 |
| ▸ | SMO | Q99835 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL798579 | 0.88 | PIK3CG (0.77) | PIK3CGPIK3CARAB9ACYP3A4SMN1; SMN2 | |
| SCHEMBL3711448 | 0.86 | DYRK1A (0.75) | PIK3CGPIK3CARAB9ACYP3A4SMN1; SMN2 | |
| SCHEMBL1651716 | 0.86 | SMN1; SMN2 (0.75) | PIK3CGPIK3CARAB9ACYP3A4SMN1; SMN2 | |
| SCHEMBL3709415 | 0.85 | PIK3CG (0.76) | PIK3CGPIK3CARAB9ACYP3A4SMN1; SMN2 | |
| SCHEMBL1651874 | 0.83 | PIK3CG (1.00) | PIK3CGPIK3CARAB9AABL1CYP3A4 | |
| SCHEMBL3714360 | 0.83 | PIK3CG (0.65) | PIK3CGPIK3CAABL1CYP3A4SMN1; SMN2 | |
| SCHEMBL3716998 | 0.82 | PIK3CG (0.79) | PIK3CGPIK3CARAB9ACYP3A4SMN1; SMN2 | |
| SCHEMBL1651394 | 0.82 | PIK3CG (0.79) | PIK3CGPIK3CARAB9AABL1CYP3A4 | |
| SCHEMBL3870265 | 0.82 | PIK3CG (0.79) | PIK3CGPIK3CARAB9AABL1CYP3A4 | |
| SCHEMBL1622337 | 0.81 | PIK3CG (0.77) | PIK3CGPIK3CARAB9ACYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133127-A1 | FUSED BICYCLIC COMPOUNDS AND USE THEREOF AS PI3K INHIBITORS | MERCK SERONO S.A. (CH) | 2009-11-05 | — | — | WO | disclosed |