Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 7/20 | 0.77 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | SMO | Q99835 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711448 | 0.90 | DYRK1A (0.75) | PIK3CGPIK3CACYP3A4DYRK1ASMN1; SMN2 | |
| SCHEMBL1651716 | 0.90 | SMN1; SMN2 (0.75) | PIK3CGPIK3CACYP3A4DYRK1ASMN1; SMN2 | |
| SCHEMBL3709415 | 0.89 | PIK3CG (0.76) | PIK3CGPIK3CACYP3A4DYRK1ASMN1; SMN2 | |
| SCHEMBL1651394 | 0.89 | PIK3CG (0.79) | PIK3CGPIK3CACYP3A4DYRK1ASMN1; SMN2 | |
| SCHEMBL13615436 | 0.88 | PIK3CG (0.70) | PIK3CGPIK3CACYP3A4DYRK1ASMN1; SMN2 | |
| SCHEMBL1651874 | 0.87 | PIK3CG (1.00) | PIK3CGPIK3CACYP3A4DYRK1ASMN1; SMN2 | |
| SCHEMBL3870265 | 0.86 | PIK3CG (0.79) | PIK3CGPIK3CACYP3A4DYRK1ASMN1; SMN2 | |
| SCHEMBL3716998 | 0.86 | PIK3CG (0.79) | PIK3CGPIK3CACYP3A4DYRK1ASMN1; SMN2 | |
| SCHEMBL19807983 | 0.85 | DYRK1A (0.79) | PIK3CGPIK3CACYP3A4DYRK1ASMN1; SMN2 | |
| SCHEMBL30561486 | 0.85 | DYRK1A (0.79) | PIK3CGPIK3CACYP3A4DYRK1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-03-22 | — | — | US | disclosed |
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | MTOR, STAT3, SLC14A1 | PIK3CG 16/4885PIK3CA 15/4885CYP3A4 4200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.