SCHEMBL1361555

SCHEMBL1361555

Cc1cc(OS(=O)(=O)C(F)(F)F)cc(Br)c1NC(=O)c1cccc(NC(=O)c2ccccc2)c1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 5/20 0.49
KCNK9 Q9NPC2 4/20 0.49
RAB9A P51151 3/20 0.48
NPC1 O15118 3/20 0.48
NLRP3 Q96P20 1/20 0.48
KMT2A Q03164 8/20 0.46
MEN1 O00255 7/20 0.46
POLB P06746 3/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
TP53 P04637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1359693 0.85 ENPP2 (0.53) KCNK3KCNK9RAB9ANPC1NLRP3
SCHEMBL27886604 0.85 TSHR (0.39) KCNK3KCNK9RAB9ANPC1KMT2A
SCHEMBL1361514 0.79 KMT2A (0.56) KCNK3KCNK9RAB9ANPC1KMT2A
SCHEMBL13875615 0.78 KCNK3 (0.50) KCNK3KCNK9RAB9AKMT2AMEN1
SCHEMBL2684118 0.77 KCNK3 (0.69) KCNK3KCNK9RAB9ANPC1KMT2A
SCHEMBL12570375 0.74 KCNK3 (0.59) KCNK3KCNK9RAB9ANPC1KMT2A
SCHEMBL29409938 0.74 KCNK3 (0.59) KCNK3KCNK9RAB9ANPC1KMT2A
SCHEMBL16863615 0.74 KCNK3 (0.55) KCNK3KCNK9RAB9ANPC1KMT2A
SCHEMBL2103913 0.74 KCNK3 (0.57) KCNK3KCNK9RAB9ANPC1KMT2A
SCHEMBL13875614 0.73 KMT2A (0.51) KCNK3KCNK9RAB9ANPC1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8067638-B2 Amide derivative and insecticide containing the same MITSUI CHEMICALS, INC. (JP) 2011-11-29 US disclosed
US-20090233962-A1 Amide derivative and insecticide containing the same MITSUI CHEMICALS, INC. (JP) 2009-09-17 US disclosed
CN-101203484-A Amide derivative and pesticide containing such compound MITSUI CHEMICALS INC (JP) 2008-06-18 CN disclosed
EP-1911751-A1 AMIDE DERIVATIVE AND PESTICIDE CONTAINING SUCH COMPOUND Mitsui Chemicals, Inc. (JP) 2008-04-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090233962-A1 Amide derivative and insecticide containing the same CYP1A1, CYP4B1, CYP2E1 KCNK3 910/4885KCNK9 1783/4885RAB9A 1871/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.