SCHEMBL13875615

SCHEMBL13875615

Cc1cc(Br)c(NC(=O)c2cccc(NC(=O)c3ccccc3)c2)c(S(=O)(=O)C(F)(F)F)c1

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 8/20 0.50
KMT2A Q03164 7/20 0.50
MEN1 O00255 6/20 0.50
KCNK9 Q9NPC2 6/20 0.50
POLB P06746 2/20 0.50
LMNA P02545 2/20 0.46
MAPT P10636 1/20 0.46
RAB9A P51151 2/20 0.46
HTT P42858 1/20 0.46
TP53 P04637 1/20 0.45
PARP1 P09874 1/20 0.45
KCNH2 Q12809 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4184912 0.86 KCNK3 (0.48) KCNK3KMT2AMEN1KCNK9POLB
SCHEMBL13875613 0.83 MAPT (0.38) KMT2AMEN1POLBLMNAMAPT
SCHEMBL13875614 0.80 KMT2A (0.51) KCNK3KMT2AMEN1KCNK9POLB
SCHEMBL1361555 0.78 KCNK3 (0.49) KCNK3KMT2AMEN1KCNK9POLB
SCHEMBL31654068 0.73 RXFP1 (0.62) KCNK3KMT2AMEN1KCNK9LMNA
SCHEMBL1361514 0.73 KMT2A (0.56) KCNK3KMT2AMEN1KCNK9POLB
SCHEMBL2684118 0.73 KCNK3 (0.69) KCNK3KMT2AMEN1KCNK9POLB
SCHEMBL1767376 0.72 KCNK3 (0.54) KCNK3KMT2AMEN1KCNK9POLB
SCHEMBL4185079 0.71 NR1H3 (0.39) KMT2AMEN1LMNAMAPTRAB9A
SCHEMBL29409938 0.71 KCNK3 (0.59) KCNK3KMT2AMEN1KCNK9POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090099204-A1 Amide derivative, insecticide containing the same and method for application thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2009-04-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090099204-A1 Amide derivative, insecticide containing the same and method for application thereof as insecticide CYP2E1, GSTA1, CYP2S1 KCNK3 504/4885KMT2A 499/4885MEN1 4524/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.