Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599918 | 0.84 | ALDH1A1 (0.50) | MAP4K4ATMLMNASMN1; SMN2NPC1 | |
| SCHEMBL1882774 | 0.84 | VNN1 (0.47) | MAP4K4ATMLMNASMN1; SMN2NPC1 | |
| SCHEMBL13115741 | 0.81 | MAP4K4 (0.49) | MAP4K4ATMLMNASMN1; SMN2NPC1 | |
| SCHEMBL3685097 | 0.80 | POLB (0.57) | LMNASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL29952768 | 0.80 | POLB (0.57) | LMNASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL10692338 | 0.80 | MAPT (0.46) | LMNANPC1RAB9ABRD4BRD9 | |
| SCHEMBL12640349 | 0.78 | CYP3A4 (0.46) | ATMSMN1; SMN2NPC1PKMRAB9A | |
| SCHEMBL19828921 | 0.77 | NPSR1 (0.51) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL19302385 | 0.77 | ATM (0.47) | ATMLMNASMN1; SMN2NPC1PKM | |
| SCHEMBL21386707 | 0.77 | MAPK10 (0.46) | LMNAPKMMAPK14MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143018-A2 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2009-11-26 | — | — | WO | disclosed |