Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13616567 | 0.88 | MAPK1 (0.49) | L3MBTL1ALDH1A1POLBMAPK1HTT | |
| SCHEMBL13616490 | 0.87 | ALDH1A1 (0.44) | L3MBTL1ALDH1A1POLBMAPK1KMT2A | |
| SCHEMBL398552 | 0.80 | KDM4E (0.58) | CYP11B1CYP11B2CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL4307358 | 0.77 | CYP2E1 (0.53) | ALDH1A1KMT2ACYP11B1CYP11B2CYP2E1 | |
| SCHEMBL13940574 | 0.77 | KMT2A (0.47) | ALDH1A1KMT2ACYP11B1CYP11B2CYP2E1 | |
| SCHEMBL11627032 | 0.76 | DRD4 (0.57) | ALDH1A1KMT2AHTTCYP2E1CYP3A4 | |
| SCHEMBL2368529 | 0.76 | AR (0.59) | ALDH1A1KMT2AHTTCYP11B1CYP11B2 | |
| SCHEMBL12420819 | 0.75 | ALDH1A1 (0.58) | ALDH1A1CYP11B1CYP11B2CYP2E1CYP3A4 | |
| SCHEMBL11625572 | 0.74 | HTR7 (0.59) | ALDH1A1POLBKMT2AHTTGAA | |
| Hydrochloric Acid SCHEMBL2197173 | 0.73 | ALDH1A1 (0.56) | ALDH1A1CYP11B1CYP11B2CYP2E1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275594-A1 | 3-HYDRAZONE PIPERAZINYL RIFAMYCIN DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275594-A1 | 3-HYDRAZONE PIPERAZINYL RIFAMYCIN DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS | RIF1, ABCC1, HDAC6 | L3MBTL1 4330/4885ALDH1A1 1070/4885POLB 839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.