Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19456620 | 0.94 | SMN1; SMN2 (0.53) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL25837453 | 0.93 | SMN1; SMN2 (0.51) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL25837450 | 0.93 | SMN1; SMN2 (0.51) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL10224055 | 0.88 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL18199495 | 0.83 | SMN1; SMN2 (0.66) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL20340484 | 0.83 | SMN1; SMN2 (0.66) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL23518474 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL20349713 | 0.83 | ALDH1A1 (0.46) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL24948947 | 0.81 | ALDH1A1 (0.48) | SMN1; SMN2TP53HPGDALDH1A1KMT2A | |
| SCHEMBL22664242 | 0.81 | ALDH1A1 (0.44) | SMN1; SMN2TP53HPGDALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4122925-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | Medshine Discovery Inc. (CN) | 2023-01-25 | — | — | EP | disclosed |
| US-9463252-B2 | Auristatin drug linker conjugates | SEATTLE GENETICS, INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-20140050746-A1 | AURISTATIN DRUG LINKER CONJUGATES | SEATTLE GENETICS, INC. (US) | 2014-02-20 | — | — | US | disclosed |
| US-8455497-B2 | Inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-06-04 | — | — | US | disclosed |
| US-8455497-B2 | Inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-06-04 | — | — | US | disclosed |
| US-20110020343-A1 | AURISTATIN DRUG LINKER CONJUGATES | SEATTLE GENETICS, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-20090274650-A1 | INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED | 2009-11-05 | — | — | US | disclosed |
| US-20090274650-A1 | INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110020343-A1 | AURISTATIN DRUG LINKER CONJUGATES | AURKA, AURKC, AURKB | SMN1; SMN2 3344/4885TP53 1115/4885HPGD 4166/4885 |
| US-20140050746-A1 | AURISTATIN DRUG LINKER CONJUGATES | AURKA, AURKC, AURKB | SMN1; SMN2 3344/4885TP53 1115/4885HPGD 4166/4885 |
| US-20090274650-A1 | INHIBITORS OF ASPARTYL PROTEASE | SPINT2, DNPEP, PRSS1 | SMN1; SMN2 2568/4885TP53 1360/4885HPGD 2979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.