Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 6/20 | 0.39 |
| ▸ | TNKS | O95271 | 4/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12217552 | 0.78 | DAO (0.40) | BRD4DAOALDH1A1 | |
| SCHEMBL6037437 | 0.77 | ALDH1A1 (0.41) | TTKAURKBINCENPBRD4BRD9 | |
| SCHEMBL20670337 | 0.76 | DAO (0.39) | TTKAURKBINCENPPARP1TNKS | |
| SCHEMBL14466317 | 0.74 | DAO (0.38) | BRD4DAO | |
| SCHEMBL18933659 | 0.74 | DAO (0.45) | BRD4DAOALDH1A1 | |
| SCHEMBL24664734 | 0.73 | DAO (0.39) | BRD4DAO | |
| SCHEMBL24666071 | 0.70 | DAO (0.38) | BRD4DAO | |
| SCHEMBL26024419 | 0.69 | LMNA (0.38) | TTKAURKBINCENPBRD4BRD9 | |
| SCHEMBL13729217 | 0.69 | KDM4E (0.41) | BRD4DAOCYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL21459463 | 0.68 | HRH3 (0.46) | TTKAURKBINCENPPARP1TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1477186-B1 | ANTIPRURITICS | SHIONOGI & CO (JP) | 2009-11-11 | — | — | EP | disclosed |