Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.55 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 8/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.41 |
| ▸ | PDE4A | P27815 | 4/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12072640 | 0.85 | PDK2 (0.55) | PDK2PDK4ATAD2PGRPDE3B | |
| SCHEMBL7433946 | 0.78 | PDK2 (0.57) | PDK2PDK4MAPK14ATAD2PGR | |
| SCHEMBL1223198 | 0.77 | PDK2 (0.55) | PDK2PDK4MAPK14ATAD2PGR | |
| SCHEMBL9559268 | 0.77 | PDK2 (0.55) | PDK2PDK4MAPK14ATAD2PGR | |
| SCHEMBL2272299 | 0.77 | PGR (0.55) | PDK2PDK4MAPK14ATAD2PGR | |
| SCHEMBL2144278 | 0.77 | PDK2 (0.55) | PDK2PDK4MAPK14ATAD2PGR | |
| SCHEMBL1972936 | 0.77 | PDK2 (0.55) | PDK2PDK4MAPK14ATAD2PGR | |
| SCHEMBL496554 | 0.77 | PDK2 (0.55) | PDK2PDK4MAPK14ATAD2PGR | |
| SCHEMBL13088966 | 0.77 | PGR (0.44) | PGR | |
| Hydrochloric Acid SCHEMBL7276702 | 0.76 | PDK2 (0.53) | PDK2PDK4MAPK14ATAD2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009132774-A1 | NEW SUBSTITUTED INDOLIN-2-ONE DERIVATIVES AND THEIR USE AS P39 MITOGEN-ACTIVATED KINASE INHIBITORS | ALMIRALL, S. A. (ES) | 2009-11-05 | — | — | WO | disclosed |
| WO-2009124692-A1 | NEW SUBSTITUTED SPIRO[CYCLOALKYL-1,3'-INDOL]-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS. | ALMIRALL, S.A. (ES) | 2009-10-15 | — | — | WO | disclosed |
| EP-2108641-A1 | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors | Laboratorios Almirall, S.A. (ES) | 2009-10-14 | — | — | EP | disclosed |