Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7407020 | 0.88 | SMN1; SMN2 (0.73) | SMN1; SMN2KDM4EHTR1BMAPK1L3MBTL1 | |
| SCHEMBL9633992 | 0.85 | KDM4E (0.52) | SMN1; SMN2KDM4EHTR1BMAPK1L3MBTL1 | |
| SCHEMBL401448 | 0.82 | KDM4E (0.75) | SMN1; SMN2KDM4EHTR1BMAPK1L3MBTL1 | |
| SCHEMBL13617356 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4EHTR1BMAPK1L3MBTL1 | |
| SCHEMBL11105088 | 0.81 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPK1L3MBTL1RAB9ATDP1 | |
| SCHEMBL902827 | 0.81 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPK1L3MBTL1RAB9ALMNA | |
| Hydrochloric Acid SCHEMBL1623557 | 0.80 | KDM4E (0.79) | SMN1; SMN2KDM4EHTR1BMAPK1L3MBTL1 | |
| Ethylamine SCHEMBL27871983 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPK1TDP1HTR2AHTR2C | |
| SCHEMBL11092732 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPK1L3MBTL1RAB9ATDP1 | |
| Hydrochloric Acid SCHEMBL25376194 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EHTR1BMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888538-B1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-(2-ARYLOXY-ETHYL)-AMINES HAVING AN ACTIVITY ON THE 5-HT RECEPTOR | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | disclosed |