Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13617356 | 0.86 | SMN1; SMN2 (0.58) | KDM4EL3MBTL1TDP1HTR1BSMN1; SMN2 | |
| SCHEMBL13617359 | 0.85 | SMN1; SMN2 (0.57) | KDM4EL3MBTL1TDP1HTR1BSMN1; SMN2 | |
| SCHEMBL9632436 | 0.84 | L3MBTL1 (0.49) | L3MBTL1TDP1SMN1; SMN2MAPK1RAB9A | |
| SCHEMBL9634005 | 0.84 | L3MBTL1 (0.49) | L3MBTL1TDP1SMN1; SMN2KMT2ACHRM2 | |
| SCHEMBL2035810 | 0.81 | L3MBTL1 (0.53) | KDM4EL3MBTL1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL21246942 | 0.80 | L3MBTL1 (0.43) | KDM4EL3MBTL1TDP1SMN1; SMN2MAPK1 | |
| SCHEMBL24096249 | 0.78 | TAAR1 (0.48) | KDM4EHTR1BSMN1; SMN2MAPK1TP53 | |
| SCHEMBL29669870 | 0.78 | NFE2L2 (0.50) | KDM4EL3MBTL1TDP1SMN1; SMN2MAPK1 | |
| SCHEMBL1627720 | 0.78 | NFE2L2 (0.50) | KDM4EL3MBTL1TDP1SMN1; SMN2MAPK1 | |
| SCHEMBL1682251 | 0.78 | KDM4E (0.55) | KDM4EL3MBTL1TDP1HTR1BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0331943-B1 | PHENOXYETHYLAMINE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND COMPOSITION FOR EXHIBITING EXCELLENT ALPHA-1-BLOCKING ACTIVITY CONTAINING THE SAME | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1992-06-17 | — | — | EP | disclosed |
| US-4971990-A | HYPOTENSIVE AGENTS, DYSUREA | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1990-11-20 | — | — | US | disclosed |
| EP-0331943-A1 | Phenoxyethylamine derivatives, process for preparing the same, and composition for exhibiting excellent alpha-1-blocking activity containing the same | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1989-09-13 | — | — | EP | disclosed |