Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | ABL2 | P42684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | F12 | P00748 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264285 | 0.88 | ESR2 (0.54) | ESR2NR1H2ABL1EGFRSRC | |
| SCHEMBL8253723 | 0.86 | ESR2 (0.52) | ESR2NR1H2ABL1EGFRSRC | |
| SCHEMBL8264299 | 0.82 | ESR2 (0.47) | ESR2NR1H2ABL1EGFRSRC | |
| SCHEMBL8264160 | 0.78 | USP30 (0.47) | ESR2NR1H2MAPK1UCHL1PDK4 | |
| SCHEMBL8264380 | 0.77 | ESR2 (0.49) | ESR2NR1H2NAMPTUSP30PTPN2 | |
| SCHEMBL8265146 | 0.76 | ESR2 (0.45) | ESR2NR1H2MAPK1NAMPTUCHL1 | |
| SCHEMBL13490542 | 0.76 | ESR2 (0.45) | ESR2NR1H2MAPK1UCHL1HDAC1 | |
| SCHEMBL7047941 | 0.76 | SLC6A3 (0.47) | ESR2NR1H2MAPK1UCHL1USP30 | |
| SCHEMBL951850 | 0.76 | ESR2 (0.48) | ESR2NR1H2MAPK1NAMPTUCHL1 | |
| SCHEMBL8261717 | 0.75 | CHRM2 (0.51) | ESR2NR1H2MAPK1NAMPTUCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |