Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 9/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.35 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.34 |
| ▸ | MARS1 | P56192 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3842403 | 0.89 | CRHR1 (0.37) | CRHR1F2RL3CNR1 | |
| SCHEMBL3841771 | 0.84 | CRHR1 (0.41) | CRHR1F2RL3MARS1KCNH2 | |
| SCHEMBL3840256 | 0.83 | CRHR1 (0.43) | CRHR1F2RL3CNR1 | |
| SCHEMBL3841756 | 0.77 | CRHR1 (0.43) | CRHR1KCNH2 | |
| SCHEMBL3846201 | 0.77 | CRHR1 (0.43) | CRHR1KCNH2 | |
| SCHEMBL3364574 | 0.76 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL3843006 | 0.76 | CRHR1 (0.44) | CRHR1KCNH2 | |
| SCHEMBL3365373 | 0.76 | CRHR1 (0.46) | CRHR1SHMT1SHMT2CNR1 | |
| SCHEMBL3844096 | 0.75 | CRHR1 (0.43) | CRHR1KCNH2 | |
| SCHEMBL3839128 | 0.75 | CRHR1 (0.51) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007753-B1 | HETEROCYCLIC GABA ALPHA SUBTYPE SELECTIVE RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-11-11 | — | — | EP | disclosed |