Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | RECQL | P46063 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17227494 | 0.91 | KDM4E (0.44) | KDM4ERECQLTDP1LMNAMAPT | |
| SCHEMBL3430968 | 0.80 | KCNH2 (0.35) | LMNAMAPTHIF1AALOX15TSHR | |
| SCHEMBL837030 | 0.77 | KDM4E (0.47) | KDM4ERECQLTDP1LMNAMAPT | |
| SCHEMBL851228 | 0.77 | KDM4E (0.47) | KDM4ERECQLTDP1LMNAMAPT | |
| SCHEMBL10297470 | 0.75 | KDM4E (0.45) | KDM4ERECQLTDP1LMNAMAPT | |
| SCHEMBL28841938 | 0.74 | HTR2C (0.34) | TSHRMTORKMT2AKCNH2P2RX3 | |
| SCHEMBL13711517 | 0.74 | KCNH2 (0.40) | LMNAMAPTHIF1AALOX15TSHR | |
| Hydrochloric Acid SCHEMBL3275614 | 0.74 | KDM4E (0.46) | KDM4ERECQLTDP1LMNAMAPT | |
| SCHEMBL12844790 | 0.73 | ADRA2A (0.34) | KCNH2ADRA2AADRA2CP2RX3 | |
| SCHEMBL24253497 | 0.70 | GABRA1 (0.39) | TSHRALDH1A1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142571-A1 | PHENYL AND BENZODIOXINYL SUBSTITUTED INDAZOLES DERIVATIVES | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | WO | disclosed |