Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ERN1 | O75460 | 4/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | BCR | P11274 | 3/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14980324 | 0.88 | POLB (0.74) | L3MBTL1KDM4ESLC6A7POLBERN1 | |
| SCHEMBL12228180 | 0.82 | POLB (0.66) | L3MBTL1POLBALDH1A1HPGDTSHR | |
| SCHEMBL10723960 | 0.82 | HPGD (0.68) | L3MBTL1KDM4EPOLBALDH1A1MAPT | |
| SCHEMBL13743318 | 0.82 | FYN (0.54) | L3MBTL1KDM4ESLC6A7POLBERN1 | |
| SCHEMBL13826415 | 0.81 | LMNA (0.51) | L3MBTL1SLC6A7POLBALDH1A1HPGD | |
| SCHEMBL16222335 | 0.81 | ERN1 (0.62) | L3MBTL1KDM4EPOLBERN1ADORA2A | |
| SCHEMBL16000477 | 0.80 | TLR9 (0.50) | L3MBTL1SLC6A7POLBALDH1A1HPGD | |
| SCHEMBL27318300 | 0.80 | MAPT (0.55) | L3MBTL1KDM4ESLC6A7POLBERN1 | |
| SCHEMBL911444 | 0.79 | SLC6A7 (0.57) | KDM4ESLC6A7POLBALDH1A1HPGD | |
| SCHEMBL14980278 | 0.78 | ERN1 (0.64) | L3MBTL1KDM4EPOLBERN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615550-B2 | Substituted piperazines,(1,4) diazepines, and 2,5-diazabicyclo (2.2.1)iieptanes as histamine H1 and/or H3 antagonists or histamine H3 reverse antagonists | GLAXO GROUP LIMITED (GB) | 2009-11-10 | — | — | US | disclosed |
| US-7615550-B2 | Substituted piperazines,(1,4) diazepines, and 2,5-diazabicyclo (2.2.1)iieptanes as histamine H1 and/or H3 antagonists or histamine H3 reverse antagonists | GLAXO GROUP LIMITED (GB) | 2009-11-10 | — | — | US | disclosed |