Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 12/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241510 | 0.91 | ABCB1 (0.61) | ABCB1HTR1ADRD2RXRARXRB | |
| SCHEMBL12301142 | 0.81 | ABCB1 (0.67) | ABCB1HTR1ADRD2MAPTHTT | |
| SCHEMBL12301149 | 0.79 | ABCB1 (0.60) | ABCB1HTR1ARXRARXRBRXRG | |
| SCHEMBL12301137 | 0.79 | RXRA (0.63) | HTR1ARXRARXRBRXRGMAPT | |
| SCHEMBL12903697 | 0.75 | MAOB (0.47) | ABCB1ENPP2MAOB | |
| SCHEMBL3764673 | 0.74 | RXRA (0.71) | HTR1ARXRARXRBRXRGMAPT | |
| SCHEMBL11258820 | 0.74 | ALDH1A1 (0.53) | — | |
| SCHEMBL2549427 | 0.73 | ABCB1 (0.60) | ABCB1HTR1ADRD2MAPTHTT | |
| SCHEMBL7909538 | 0.73 | ABCB1 (0.60) | ABCB1HTR1ADRD2MAPTENPP2 | |
| SCHEMBL29874217 | 0.73 | MAPK1 (0.70) | HTR1ADRD2RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |