SCHEMBL13618861

SCHEMBL13618861

C/C=C(\N)c1ccncc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAPRT Q6XQN6 1/20 0.42
CYP2D6 P10635 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MPO P05164 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
ADORA3 P0DMS8 1/20 0.41
CYP2A6 P11509 1/20 0.41
CYP2C19 P33261 1/20 0.41
CA1 P00915 1/20 0.39
CA9 Q16790 1/20 0.39
HTT P42858 1/20 0.39
ALDH1A1 P00352 2/20 0.39
PLG P00747 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
LMNA P02545 2/20 0.38
MAPT P10636 1/20 0.38
CHRM1 P11229 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13357374 0.78 NAPRT (0.46) NAPRTCYP2D6KDM4EMPOCYP1A2
SCHEMBL27329368 0.75 NAPRT (0.38) NAPRTCYP2D6KDM4EMPOCYP1A2
SCHEMBL4711728 0.75 NAPRT (0.43) NAPRTCYP2D6KDM4EMPOCYP1A2
SCHEMBL10669214 0.74 BLM (0.48) NAPRTCYP3A4CYP2C19CA1CA9
SCHEMBL5031672 0.74 CYP19A1 (0.46) NAPRTCYP2D6KDM4EMPOCYP1A2
SCHEMBL6259239 0.74 BLM (0.48) NAPRTCYP3A4CYP2C19CA1CA9
SCHEMBL4711727 0.73 NAPRT (0.41) NAPRTCYP2D6KDM4EMPOCYP1A2
SCHEMBL17610285 0.73 RECQL (0.60) NAPRTCYP2D6KDM4EMPOCYP1A2
SCHEMBL16900870 0.73 NAPRT (0.37) NAPRTCYP2D6KDM4EMPOCYP1A2
SCHEMBL5026268 0.73 RECQL (0.60) NAPRTCYP2D6KDM4EMPOCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2116545-A1 Process for preparing cefsulodin sodium IDEXX LABORATORIES, INC. (US) 2009-11-11 EP disclosed
WO-2009057827-A1 PYRIDAZINONE DERIVATIVES AND USE THEREOF AS P2X7 RECEPTOR INHIBITORS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-05-07 WO disclosed