Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.34 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8598240 | 0.86 | FABP3 (0.37) | FABP3SMN1; SMN2ADRA1ALMNAESR1 | |
| SCHEMBL25857265 | 0.84 | SMN1; SMN2 (0.46) | FABP3SMN1; SMN2ADRA1ALMNAESR1 | |
| SCHEMBL100728 | 0.84 | FABP3 (0.39) | FABP3SMN1; SMN2ADRA1ALMNAESR1 | |
| SCHEMBL65991 | 0.82 | FABP3 (0.39) | FABP3SMN1; SMN2ADRA1ALMNAESR1 | |
| SCHEMBL13745842 | 0.79 | FABP3 (0.43) | FABP3SMN1; SMN2ADRA1ALMNAESR1 | |
| SCHEMBL14257803 | 0.78 | CHRNA7 (0.47) | CHRM1CHRM3CHRM2CHRM4CHRNA7 | |
| SCHEMBL16638189 | 0.77 | SMN1; SMN2 (0.49) | FABP3SMN1; SMN2ADRA1ALMNAESR1 | |
| SCHEMBL13619237 | 0.77 | LMNA (0.58) | FABP3SMN1; SMN2ADRA1ALMNAESR1 | |
| SCHEMBL13123029 | 0.77 | SMN1; SMN2 (0.45) | FABP3SMN1; SMN2ADRA1ALMNAESR1 | |
| SCHEMBL1692413 | 0.77 | LMNA (0.49) | FABP3SMN1; SMN2ADRA1ALMNAESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615543-B2 | Complexes with C-reactive protein (CRP) molecules; rheumatoid arthritis, juvenile chronic (rheumatoid) arthritis, ankylosing spondylitis, psoriatic arthritis, systemic vasculitis, polymyalgia rheumatica, Reiter's disease, Crohn's disease and familial Mediterranean fever | PENTRAXIN THERAPEUTICS LIMITED (GB) | 2009-11-10 | — | — | US | disclosed |