Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 7/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGAV | P06756 | 1/20 | 0.45 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PEPD | P12955 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538232 | 0.80 | ALDH1A1 (0.48) | ALDH1A1HPGDACEITGB3ITGB1 | |
| SCHEMBL6439668 | 0.78 | F2 (0.62) | ALDH1A1ACEITGB3ITGB1ITGAV | |
| SCHEMBL6439663 | 0.78 | F2 (0.62) | ALDH1A1ACEITGB3ITGB1ITGAV | |
| SCHEMBL9536140 | 0.77 | ALDH1A1 (0.57) | ALDH1A1HPGDACEITGB3ITGB1 | |
| SCHEMBL3183657 | 0.72 | ACE (0.55) | ALDH1A1HPGDACEKMT2A | |
| SCHEMBL3183667 | 0.72 | ACE (0.55) | ALDH1A1HPGDACEKMT2A | |
| SCHEMBL6039762 | 0.72 | ACE (0.55) | ALDH1A1HPGDACEKMT2A | |
| SCHEMBL6786426 | 0.72 | ACE (0.55) | ALDH1A1HPGDACEKMT2A | |
| SCHEMBL2448827 | 0.71 | ACE (0.51) | ALDH1A1ACEKMT2A | |
| SCHEMBL6039476 | 0.71 | ACE (0.51) | ALDH1A1ACEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615543-B2 | Complexes with C-reactive protein (CRP) molecules; rheumatoid arthritis, juvenile chronic (rheumatoid) arthritis, ankylosing spondylitis, psoriatic arthritis, systemic vasculitis, polymyalgia rheumatica, Reiter's disease, Crohn's disease and familial Mediterranean fever | PENTRAXIN THERAPEUTICS LIMITED (GB) | 2009-11-10 | — | — | US | disclosed |