Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1293117 | 0.88 | LMNA (0.50) | LMNAKMT2AMEN1 | |
| SCHEMBL21910602 | 0.83 | TSHR (0.42) | KMT2AMEN1MAPTKLK7 | |
| SCHEMBL6546873 | 0.82 | SMN1; SMN2 (0.43) | LMNAALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL27504862 | 0.81 | ESR1 (0.50) | LMNAALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL29338452 | 0.80 | ALDH1A1 (0.36) | LMNAALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL17802355 | 0.79 | LMNA (0.46) | LMNAALDH1A1KDM4ECYP3A4CYP2D6 | |
| SCHEMBL17069292 | 0.79 | NPC1 (0.44) | LMNAALDH1A1KDM4ECYP3A4CYP2D6 | |
| SCHEMBL17069287 | 0.79 | NPC1 (0.44) | LMNAALDH1A1KDM4ECYP3A4CYP2D6 | |
| SCHEMBL360080 | 0.79 | LMNA (0.46) | LMNAALDH1A1KDM4ECYP3A4CYP2D6 | |
| SCHEMBL683626 | 0.79 | NPC1 (0.44) | LMNAALDH1A1KDM4ECYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143049-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |