Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GNAI3 | P08754 | 4/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24700245 | 0.88 | DRD3 (0.39) | — | |
| SCHEMBL12859391 | 0.85 | HTR2A (0.34) | KMT2AGNAI3GNAO1GNAI1HTR2A | |
| SCHEMBL688401 | 0.83 | NCF1 (0.41) | KMT2AGNAI3GNAO1GNAI1HTR2A | |
| SCHEMBL3373689 | 0.83 | ADH1C (0.41) | KMT2AGRIN2B | |
| SCHEMBL23252489 | 0.83 | KMT2A (0.50) | KMT2AGNAI3GNAO1GNAI1MEN1 | |
| SCHEMBL12120557 | 0.81 | KMT2A (0.49) | KMT2AGNAI3GNAO1GNAI1MEN1 | |
| SCHEMBL21186834 | 0.81 | KMT2A (0.35) | KMT2AGNAI3GNAO1GNAI1PGR | |
| SCHEMBL17285938 | 0.81 | KMT2A (0.40) | KMT2AGNAI3GNAO1GNAI1HTR2A | |
| SCHEMBL16122029 | 0.81 | NCF1 (0.38) | KMT2AHTR2AHTR2CMEN1RAB9A | |
| SCHEMBL18469956 | 0.81 | NCF1 (0.38) | KMT2AGNAI3GNAO1GNAI1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143389-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | WO | disclosed |