Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 19/20 | 0.59 |
| ▸ | GIPR | P48546 | 9/20 | 0.49 |
| ▸ | VIPR2 | P41587 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.49 |
| ▸ | VIPR1 | P32241 | 1/20 | 0.49 |
| ▸ | DUSP2 | Q05923 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GLP1R | P43220 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL675778 | 0.83 | GCGR (0.86) | GCGRGIPRVIPR2CYP1A2CYP3A4 | |
| SCHEMBL16365982 | 0.70 | APP (0.58) | CYP1A2NPC1 | |
| SCHEMBL2642906 | 0.70 | GCGR (0.61) | GCGRGIPRVIPR2CYP1A2CYP3A4 | |
| SCHEMBL13755866 | 0.70 | GCGR (0.54) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2643409 | 0.70 | GCGR (0.49) | GCGRGIPRVIPR2GLP1R | |
| SCHEMBL12847094 | 0.69 | GCGR (0.79) | GCGRGIPRVIPR2CYP1A2CYP3A4 | |
| SCHEMBL12846897 | 0.68 | APP (0.46) | GCGRNPC1 | |
| SCHEMBL13619215 | 0.68 | GCGR (0.77) | GCGRGIPRVIPR2CYP1A2CYP3A4 | |
| SCHEMBL1926254 | 0.68 | NPC1 (0.69) | NPC1 | |
| SCHEMBL2251012 | 0.67 | GCGR (0.87) | GCGRGIPRVIPR2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140342-A1 | GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | SCHERING CORPORATION (US) | 2009-11-19 | — | — | WO | disclosed |