Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12370614 | 0.82 | CTSL (0.64) | GRM7GAACTSLMEN1KMT2A | |
| SCHEMBL12372032 | 0.82 | CTSL (0.53) | GRM7GAACTSLMEN1KMT2A | |
| SCHEMBL12370609 | 0.82 | CTSL (0.53) | GRM7GAACTSLMEN1KMT2A | |
| SCHEMBL12371543 | 0.81 | CTSL (0.60) | GRM7GAACTSLMEN1KMT2A | |
| SCHEMBL12372031 | 0.77 | CTSL (0.58) | GRM7GAACTSLMEN1KMT2A | |
| SCHEMBL12370558 | 0.76 | CTSL (0.68) | GRM7GAACTSLMEN1KMT2A | |
| SCHEMBL12370550 | 0.75 | CTSL (0.66) | GRM7GAACTSLMEN1KMT2A | |
| SCHEMBL12371583 | 0.74 | CTSL (0.55) | GAACTSLMEN1KMT2AALDH1A1 | |
| SCHEMBL12371620 | 0.74 | CTSL (0.55) | GAACTSLMEN1KMT2AALDH1A1 | |
| SCHEMBL12372025 | 0.74 | CTSL (0.71) | GRM7GAACTSLMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136997-A2 | INHIBITORS OF HUMAN CATHEPSIN L, CATHEPSIN B, AND CATHEPSIN S | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-11-12 | — | — | WO | disclosed |