Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.45 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.42 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10202148 | 0.86 | ALDH1A1 (0.55) | HDAC6HDAC1KDRUSP30ERCC5 | |
| SCHEMBL2605695 | 0.80 | HDAC6 (0.60) | HDAC6HDAC1KDRUSP30ERCC5 | |
| SCHEMBL15074686 | 0.78 | HPGD (0.57) | HDAC6HDAC1KDRUSP30ERCC5 | |
| SCHEMBL13927796 | 0.76 | ALOX15 (0.56) | HDAC6HDAC1KDRUSP30ERCC5 | |
| SCHEMBL25139544 | 0.75 | ERCC5 (0.53) | HDAC6HDAC1KDRUSP30ERCC5 | |
| SCHEMBL21298951 | 0.75 | KDR (0.56) | HDAC6HDAC1KDRUSP30ERCC5 | |
| SCHEMBL4516395 | 0.74 | POLB (0.71) | HDAC6HDAC1NPSR1L3MBTL1POLB | |
| SCHEMBL17871614 | 0.73 | HDAC6 (0.61) | HDAC6HDAC1KDRUSP30 | |
| SCHEMBL24112826 | 0.73 | KDR (0.53) | HDAC6HDAC1KDRUSP30ERCC5 | |
| SCHEMBL13437383 | 0.72 | KDR (0.56) | HDAC6HDAC1KDRERCC5FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286984-A1 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | Mirati Therapeutics, Inc. | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286984-A1 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | MAP3K19, MAP3K9, MAP4K2 | HDAC6 3301/4885HDAC1 3154/4885KDR 526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.