Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.34 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | USP1 | O94782 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13620502 | 0.95 | CHEK1 (0.37) | KDM1ABRD4ATAD2HSP90AA1HSP90B1 | |
| SCHEMBL13620503 | 0.95 | CHEK1 (0.37) | KDM1ABRD4ATAD2HSP90AA1HSP90B1 | |
| SCHEMBL13620280 | 0.94 | HSP90AA1 (0.36) | HSP90AA1HSP90B1TRAP1DDR1USP1 | |
| SCHEMBL13608322 | 0.90 | HSP90AA1 (0.44) | KDM1ABRD4ATAD2HSP90AA1HSP90B1 | |
| SCHEMBL13608142 | 0.89 | KDM1A (0.44) | KDM1ABRD4ATAD2HSP90AA1HSP90B1 | |
| SCHEMBL13608341 | 0.89 | KDM1A (0.44) | KDM1ABRD4ATAD2MAOBHTR6 | |
| SCHEMBL13608260 | 0.87 | BRD4 (0.42) | KDM1ABRD4ATAD2HSP90AA1HSP90B1 | |
| SCHEMBL13608264 | 0.85 | KDM1A (0.39) | KDM1ABRD4ATAD2DDR1JAK2 | |
| SCHEMBL13608434 | 0.84 | KDM1A (0.45) | KDM1ABRD4ATAD2MAOBHTR6 | |
| SCHEMBL12371714 | 0.84 | KDM1A (0.43) | KDM1ABRD4ATAD2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PRKCE, PRKCZ, PRKCQ | KDM1A 1070/4885BRD4 1920/4885ATAD2 3413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.