Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.36 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 11/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | USP1 | O94782 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13620234 | 0.94 | KDM1A (0.39) | HSP90AA1HSP90B1TRAP1DDR1USP1 | |
| SCHEMBL13620502 | 0.92 | CHEK1 (0.37) | HSP90AA1HSP90B1TRAP1USP1 | |
| SCHEMBL13620503 | 0.92 | CHEK1 (0.37) | HSP90AA1HSP90B1TRAP1USP1 | |
| SCHEMBL13608231 | 0.86 | ADORA3 (0.38) | HSP90AA1HSP90B1TRAP1DDR1IDH1 | |
| SCHEMBL13620235 | 0.83 | HSP90AA1 (0.41) | HSP90AA1HSP90B1TRAP1DDR1IDH1 | |
| SCHEMBL13608322 | 0.82 | HSP90AA1 (0.44) | HSP90AA1HSP90B1TRAP1DDR1IDH1 | |
| SCHEMBL13620506 | 0.82 | HSP90AA1 (0.40) | HSP90AA1HSP90B1TRAP1DDR1IDH1 | |
| SCHEMBL13608341 | 0.81 | KDM1A (0.44) | DDR1MEN1ALDH1A1POLBKMT2A | |
| SCHEMBL13608142 | 0.81 | KDM1A (0.44) | HSP90AA1HSP90B1TRAP1DDR1IDH1 | |
| SCHEMBL12371780 | 0.80 | EPHX2 (0.43) | EPHX2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PRKCE, PRKCZ, PRKCQ | HSP90AA1 3427/4885HSP90B1 2327/4885TRAP1 2493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.