Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 3/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.54 |
| ▸ | SIK1 | P57059 | 1/20 | 0.45 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.45 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | USP1 | O94782 | 1/20 | 0.38 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | STK17B | O94768 | 2/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13620065 | 0.91 | TRAP1 (0.42) | TRAP1HSP90AA1HSP90B1SIK1SIK2 | |
| SCHEMBL13608317 | 0.88 | JAK2 (0.43) | TRAP1HSP90AA1HSP90B1SIK1SIK2 | |
| SCHEMBL12371649 | 0.88 | HSP90AA1 (0.42) | TRAP1HSP90AA1HSP90B1SIK1SIK2 | |
| SCHEMBL13608502 | 0.86 | TLR7 (0.44) | TRAP1HSP90AA1HSP90B1SIK1SIK2 | |
| SCHEMBL13608311 | 0.85 | SIK2 (0.42) | TRAP1HSP90AA1HSP90B1SIK1SIK2 | |
| SCHEMBL12371737 | 0.85 | SYK (0.48) | SYKADORA2BUSP1CTSC | |
| SCHEMBL12371660 | 0.84 | PRKCQ (0.46) | SIK1SIK2SIK3ADORA3USP1 | |
| SCHEMBL13608329 | 0.83 | HSP90AA1 (0.52) | TRAP1HSP90AA1HSP90B1SIK1SIK2 | |
| SCHEMBL13608414 | 0.83 | HSP90AA1 (0.40) | TRAP1HSP90AA1HSP90B1SIK1SIK2 | |
| SCHEMBL12371672 | 0.82 | ADORA2A (0.43) | SYKADORA3ADORA2ASTK17ATLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PRKCE, PRKCZ, PRKCQ | TRAP1 2493/4885HSP90AA1 3427/4885HSP90B1 2327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.