Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.45 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | ME2 | P23368 | 1/20 | 0.39 |
| ▸ | ME1 | P48163 | 1/20 | 0.39 |
| ▸ | ME3 | Q16798 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4456715 | 0.91 | LMNA (0.53) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL13620516 | 0.88 | LMNA (0.45) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL4248134 | 0.80 | LMNA (0.64) | LMNATSHR | |
| SCHEMBL4453428 | 0.80 | TSHR (0.56) | CACNA2D1CACNB1CACNA1BCACNA1CLMNA | |
| SCHEMBL13620078 | 0.78 | LMNA (0.57) | LMNATSHR | |
| SCHEMBL13671111 | 0.78 | LMNA (0.54) | LMNATSHR | |
| SCHEMBL13671109 | 0.78 | LMNA (0.56) | CACNA2D1CACNB1CACNA1BCACNA1CLMNA | |
| SCHEMBL4450270 | 0.78 | LMNA (0.56) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL4456969 | 0.74 | TSHR (0.51) | LMNATSHR | |
| SCHEMBL4453699 | 0.74 | LMNA (0.53) | LMNATSHRCYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009132452-A1 | DIARYL-CYCLYLALKYL DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2009-11-05 | — | — | WO | disclosed |