Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4456722 | 0.80 | TSHR (0.59) | LMNATSHRPOLBMAPTALDH1A1 | |
| SCHEMBL13620516 | 0.70 | LMNA (0.45) | LMNATSHRMEN1KMT2AATM | |
| SCHEMBL13620294 | 0.68 | CACNA2D1 (0.45) | LMNATSHRMAPK1 | |
| SCHEMBL4452309 | 0.67 | TSHR (0.43) | LMNATSHRMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4447544 | 0.67 | LMNA (0.72) | LMNATSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL4248134 | 0.65 | LMNA (0.64) | LMNATSHRMEN1KMT2AMAPT | |
| SCHEMBL1839339 | 0.64 | MAPT (0.58) | LMNATSHRPOLBMEN1KMT2A | |
| SCHEMBL13671109 | 0.63 | LMNA (0.56) | LMNATSHRPOLBHTT | |
| SCHEMBL8212831 | 0.61 | ESR1 (0.43) | LMNATSHRPOLBMEN1KMT2A | |
| SCHEMBL4081515 | 0.60 | LMNA (0.61) | LMNATSHRMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009132452-A1 | DIARYL-CYCLYLALKYL DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2009-11-05 | — | — | WO | disclosed |