Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.42 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.42 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.37 |
| ▸ | MTOR | P42345 | 3/20 | 0.36 |
| ▸ | USP1 | O94782 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | STK17B | O94768 | 1/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.34 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12371713 | 0.90 | JAK2 (0.45) | HSP90AA1HSP90B1TRAP1JAK2JAK3 | |
| SCHEMBL13608329 | 0.90 | HSP90AA1 (0.52) | HSP90AA1HSP90B1TRAP1JAK2JAK3 | |
| SCHEMBL13608439 | 0.89 | TLR7 (0.43) | HSP90AA1HSP90B1TRAP1JAK2JAK3 | |
| SCHEMBL13620065 | 0.87 | TRAP1 (0.42) | HSP90AA1HSP90B1TRAP1JAK2JAK3 | |
| SCHEMBL12371703 | 0.86 | JAK2 (0.44) | JAK2JAK3TLR7USP1ADORA3 | |
| SCHEMBL13620069 | 0.85 | DDR1 (0.38) | HSP90AA1HSP90B1TRAP1JAK2JAK3 | |
| SCHEMBL13608216 | 0.83 | CDK2 (0.40) | JAK2JAK3TLR7MTORUSP1 | |
| SCHEMBL12371712 | 0.83 | JAK2 (0.43) | HSP90AA1HSP90B1TRAP1JAK2JAK3 | |
| SCHEMBL12371691 | 0.83 | JAK2 (0.54) | JAK2JAK3TLR7USP1ADORA3 | |
| SCHEMBL13620513 | 0.82 | JAK2 (0.45) | JAK2JAK3TLR7USP1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PRKCE, PRKCZ, PRKCQ | HSP90AA1 3427/4885HSP90B1 2327/4885TRAP1 2493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.