Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | SNCA | P37840 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13620319 | 0.90 | METAP2 (0.44) | NFE2L2METAP2HDAC6SNCAGPR119 | |
| SCHEMBL4062300 | 0.79 | NFE2L2 (0.48) | NFE2L2HTR2AHTR2CKCNH2KDM4E | |
| SCHEMBL4062306 | 0.79 | NFE2L2 (0.48) | NFE2L2HTR2AHTR2CKCNH2KDM4E | |
| SCHEMBL4051608 | 0.75 | NFE2L2 (0.40) | NFE2L2GPR119 | |
| SCHEMBL4051602 | 0.75 | NFE2L2 (0.40) | NFE2L2GPR119 | |
| SCHEMBL4057657 | 0.74 | NFE2L2 (0.44) | NFE2L2NR3C2HDAC6PTGS1PTGS2 | |
| SCHEMBL4057664 | 0.74 | NFE2L2 (0.44) | NFE2L2NR3C2HDAC6PTGS1PTGS2 | |
| SCHEMBL23064075 | 0.74 | NFE2L2 (0.54) | NFE2L2HDAC6PTGS1PTGS2HTR2A | |
| SCHEMBL26327019 | 0.74 | NFE2L2 (0.54) | NFE2L2HDAC6PTGS1PTGS2HTR2A | |
| SCHEMBL4054688 | 0.71 | METAP2 (0.44) | NFE2L2METAP2GPR119KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |