Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 5/20 | 0.53 |
| ▸ | VSIR | Q9H7M9 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13620568 | 0.88 | VSIR (0.56) | TLR9VSIRMAPTMEN1KMT2A | |
| SCHEMBL4053044 | 0.86 | MAPT (0.52) | TLR9VSIRMAPTMEN1KMT2A | |
| SCHEMBL4055094 | 0.85 | TLR9 (0.50) | TLR9VSIRMAPTMEN1KMT2A | |
| SCHEMBL12322266 | 0.84 | TP53 (0.52) | TLR9MAPTMEN1KMT2ATP53 | |
| SCHEMBL4059683 | 0.80 | NPC1 (0.65) | VSIRMAPTKMT2AGPR119TP53 | |
| SCHEMBL13608739 | 0.80 | TLR9 (0.59) | TLR9VSIRGPR119TLR7RAB9A | |
| SCHEMBL10682119 | 0.79 | LTA4H (0.55) | — | |
| SCHEMBL26686711 | 0.77 | NPC1 (0.71) | VSIRMAPTMEN1KMT2AGPR119 | |
| SCHEMBL4059361 | 0.77 | VSIR (0.53) | TLR9VSIRMAPTMEN1KMT2A | |
| SCHEMBL4054393 | 0.77 | VSIR (0.53) | TLR9VSIRMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |