Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.40 |
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | PIM1 | P11309 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13620507 | 0.89 | PIM1 (0.38) | PIM1SLC6A2SLC6A4CHRM1FLT3 | |
| SCHEMBL13608282 | 0.87 | BRD4 (0.42) | PIM1CHRM1BIRC2PIM3PRMT5 | |
| SCHEMBL13620277 | 0.87 | PIM1 (0.42) | ADORA2AEPHX2PIM1BIRC2FLT3 | |
| SCHEMBL12371641 | 0.86 | CHEK1 (0.41) | ADORA2AEPHX2PPARGSLC6A2SLC6A4 | |
| SCHEMBL12371650 | 0.86 | CHEK1 (0.41) | ADORA2AEPHX2PPARGSLC6A2SLC6A4 | |
| SCHEMBL12371657 | 0.86 | CHEK1 (0.41) | ADORA2AEPHX2PPARGSLC6A2SLC6A4 | |
| SCHEMBL12371680 | 0.81 | CHEK1 (0.42) | ADORA2AEPHX2PPARGFLT3DPP4 | |
| SCHEMBL12371683 | 0.81 | CHEK1 (0.42) | ADORA2AEPHX2PPARGFLT3DPP4 | |
| SCHEMBL12371687 | 0.81 | PRKCQ (0.44) | ADORA2AEPHX2PPARGCHRM1FLT3 | |
| SCHEMBL2269378 | 0.80 | BIRC2 (0.39) | PIM1BIRC2FLT3KCNH2PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PRKCE, PRKCZ, PRKCQ | ADORA2A 975/4885EPHX2 1887/4885PPARG 1542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.