Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13620505 | 0.89 | ADORA2A (0.41) | PIM1DPP4FLT3KCNH2PIM3 | |
| SCHEMBL12371642 | 0.87 | CHEK1 (0.41) | DPP4CHEK1FLT3SLC6A2SLC6A4 | |
| SCHEMBL12371637 | 0.87 | CHEK1 (0.41) | DPP4CHEK1FLT3SLC6A2SLC6A4 | |
| SCHEMBL12371681 | 0.87 | CHEK1 (0.41) | DPP4CHEK1FLT3SLC6A2SLC6A4 | |
| SCHEMBL13620277 | 0.82 | PIM1 (0.42) | PIM1DPP4FLT3KCNH2PIM3 | |
| SCHEMBL13620037 | 0.81 | CHEK1 (0.39) | CHEK1FLT3CCNT1BRD4ATAD2 | |
| SCHEMBL13608282 | 0.80 | BRD4 (0.42) | PIM1PIM3BRD4ATAD2CHRM1 | |
| SCHEMBL13608271 | 0.79 | CCNT1 (0.39) | DDR1CCNT1BRD4ATAD2 | |
| SCHEMBL13620392 | 0.79 | DDR1 (0.42) | PIM1DDR1FLT3KCNH2PIM3 | |
| SCHEMBL13620236 | 0.79 | PIM1 (0.42) | PIM1DDR1FLT3KCNH2PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281075-A1 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PRKCE, PRKCZ, PRKCQ | PIM1 596/4885DDR1 3201/4885DPP4 3354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.