Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3226492 | 0.82 | NR3C1 (0.62) | BRD4CREBBPNR3C1PGRATAD2 | |
| SCHEMBL17680795 | 0.66 | CREBBP (1.00) | BRD4CREBBP | |
| SCHEMBL3231379 | 0.65 | NR3C1 (0.63) | BRD4NR3C1PGR | |
| SCHEMBL3226272 | 0.64 | NR3C1 (0.59) | BRD4NR3C1PGRATRABL1 | |
| SCHEMBL3219690 | 0.63 | NR3C1 (0.66) | BRD4NR3C1PGR | |
| SCHEMBL30775188 | 0.62 | METAP2 (0.50) | BRD4CREBBPMETAP2LRRK2 | |
| SCHEMBL3231133 | 0.62 | NR3C1 (0.86) | NR3C1PGR | |
| SCHEMBL12315709 | 0.61 | METAP2 (0.64) | BRD4CREBBPATAD2METAP2 | |
| SCHEMBL3227855 | 0.59 | NR3C1 (0.60) | NR3C1PGR | |
| SCHEMBL3227845 | 0.59 | NR3C1 (0.60) | NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116538-A1 | CONDENSED TETRAHYDROQUINOLINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | Mitsubishi Tanabe Pharma Corporation (JP) | 2009-11-11 | — | — | EP | disclosed |