SCHEMBL1362249

SCHEMBL1362249

FC(F)(F)Sc1[c]c(Cl)cc(-c2ccccc2C(F)(F)F)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 2/20 0.38
HSD11B1 P28845 5/20 0.36
TRPA1 O75762 5/20 0.36
SCN9A Q15858 3/20 0.35
TRPM8 Q7Z2W7 2/20 0.35
BACE1 P56817 1/20 0.35
USP2 O75604 1/20 0.34
ALDH1A1 P00352 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
CYP2C19 P33261 1/20 0.34
CLK4 Q9HAZ1 1/20 0.34
TRPV1 Q8NER1 1/20 0.34
GABRP O00591 1/20 0.33
GABRD O14764 1/20 0.33
GABRA1 P14867 1/20 0.33
GABRB1 P18505 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1361006 0.83 ALOX5AP (0.35) SCN9A
SCHEMBL1360979 0.73
SCHEMBL28619486 0.71 HSD11B1 (0.56) ARHSD11B1TRPA1SCN9ATRPM8
SCHEMBL23934168 0.69 AR (0.50) ARHSD11B1TRPA1SCN9ATRPM8
SCHEMBL1360453 0.69 KIF11 (0.42) HSD11B1GABRPGABRDGABRA1GABRB1
SCHEMBL4579025 0.66
SCHEMBL22304414 0.66 AR (0.58) ARHSD11B1TRPA1SCN9ATRPM8
SCHEMBL455997 0.66 AR (0.44) ARHSD11B1TRPA1SCN9ATRPM8
SCHEMBL24017176 0.66 AR (0.50) ARHSD11B1TRPA1SCN9ATRPM8
SCHEMBL24017164 0.66 AR (0.50) ARHSD11B1TRPA1SCN9ATRPM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8067638-B2 Amide derivative and insecticide containing the same MITSUI CHEMICALS, INC. (JP) 2011-11-29 US disclosed
US-20090233962-A1 Amide derivative and insecticide containing the same MITSUI CHEMICALS, INC. (JP) 2009-09-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090233962-A1 Amide derivative and insecticide containing the same CYP1A1, CYP4B1, CYP2E1 AR 2179/4885HSD11B1 1316/4885TRPA1 577/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.