Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | MERTK | Q12866 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL424128 | 0.77 | SMN1; SMN2 (0.51) | SMN1; SMN2JAK2ZAP70SYKMERTK | |
| SCHEMBL13622499 | 0.77 | JAK2 (0.64) | JAK2ZAP70SYKTDP1CHEK1 | |
| SCHEMBL13622503 | 0.76 | JAK2 (0.45) | SMN1; SMN2JAK2ZAP70SYKHPGD | |
| SCHEMBL13015062 | 0.71 | SMN1; SMN2 (0.57) | SMN1; SMN2HPGDALDH1A1HIF1APDE10A | |
| Hydrochloric Acid SCHEMBL3772388 | 0.70 | SMN1; SMN2 (0.56) | SMN1; SMN2HPGDALDH1A1HIF1APDE10A | |
| Hydrochloric Acid SCHEMBL4048123 | 0.70 | SMN1; SMN2 (0.56) | SMN1; SMN2HPGDALDH1A1HIF1APDE10A | |
| Hydrochloric Acid SCHEMBL4048122 | 0.70 | SMN1; SMN2 (0.56) | SMN1; SMN2HPGDALDH1A1HIF1APDE10A | |
| SCHEMBL14267590 | 0.69 | ALDH1A1 (0.56) | ALDH1A1LMNAHTTMAPTTDP1 | |
| SCHEMBL4095286 | 0.68 | MAPT (0.54) | SMN1; SMN2MERTKHPGDALDH1A1LMNA | |
| SCHEMBL30944998 | 0.68 | MAPT (0.52) | SMN1; SMN2JAK2MERTKMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615552-B2 | Fused heterocyclic compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2009-11-10 | — | — | US | disclosed |