Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13622499 | 0.85 | JAK2 (0.64) | JAK2ZAP70SYKCHEK1LRRK2 | |
| SCHEMBL13610138 | 0.76 | CHEK1 (0.48) | JAK2ZAP70SYKCHEK1LRRK2 | |
| SCHEMBL13622693 | 0.76 | SMN1; SMN2 (0.49) | JAK2ZAP70SYKCHEK1LRRK2 | |
| SCHEMBL14267590 | 0.68 | ALDH1A1 (0.56) | MAPTALDH1A1LMNAHTTKMT2A | |
| SCHEMBL12773823 | 0.67 | CHEK1 (0.55) | JAK2ZAP70SYKCHEK1LRRK2 | |
| SCHEMBL13986102 | 0.64 | TYK2 (0.41) | SYKHSD17B10 | |
| SCHEMBL13610137 | 0.62 | CHEK1 (0.67) | JAK2ZAP70SYKCHEK1LRRK2 | |
| SCHEMBL13439743 | 0.60 | RAF1 (0.42) | MAPTTP53ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL13439915 | 0.60 | MAPT (0.40) | MAPTTP53ALDH1A1LMNAHTT | |
| SCHEMBL3324581 | 0.60 | PIK3CA (0.49) | JAK2CHEK1LRRK2MAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615552-B2 | Fused heterocyclic compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2009-11-10 | — | — | US | disclosed |