Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25719380 | 0.76 | ALDH1A1 (0.50) | KDM4EMAPTPIK3CAALDH1A1HPGD | |
| SCHEMBL25719390 | 0.73 | ALDH1A1 (0.50) | KDM4EMAPTPIK3CAALDH1A1HPGD | |
| SCHEMBL27953666 | 0.69 | PIK3CA (0.72) | KDM4EPIK3CAPOLBMTORPIK3R1 | |
| SCHEMBL3776763 | 0.69 | SMN1; SMN2 (0.61) | KDM4EMAPTPIK3CAALDH1A1HPGD | |
| SCHEMBL11739973 | 0.68 | KDM4E (0.63) | KDM4EPIK3CAALDH1A1HPGDGLA | |
| SCHEMBL25719399 | 0.68 | PIK3CA (0.60) | KDM4EMAPTPIK3CAALDH1A1HPGD | |
| SCHEMBL11739337 | 0.68 | ATM (0.70) | KDM4EMAPTPIK3CAALDH1A1HPGD | |
| SCHEMBL25724448 | 0.68 | PIK3CA (0.62) | PIK3CAPOLBMTORPIK3R1 | |
| SCHEMBL4113454 | 0.67 | SMN1; SMN2 (0.59) | KDM4EMAPTPIK3CAALDH1A1HPGD | |
| SCHEMBL9404419 | 0.67 | SMN1; SMN2 (0.59) | KDM4EMAPTPIK3CAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318730-B2 | Fused hetrocyclic compounds | SYNTA PHARMACEUTICALS CORPORATION (US) | 2012-11-27 | — | — | US | disclosed |
| US-7615552-B2 | Fused heterocyclic compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2009-11-10 | — | — | US | disclosed |
| US-20090253694-A1 | Fused hetrocyclic compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253694-A1 | Fused hetrocyclic compounds | IL2, IL15, IL4 | KDM4E 3697/4885MAPT 2861/4885PIK3CA 1307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.