Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.55 |
| ▸ | PER2 | O15055 | 1/20 | 0.37 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8282119 | 1.00 | PIK3CD (0.55) | PIK3CDPER2CRY2GRM2GRIN1 | |
| SCHEMBL8282110 | 0.79 | SMN1; SMN2 (0.38) | PER2CRY2 | |
| SCHEMBL8045418 | 0.77 | PIK3CD (0.46) | PIK3CDPER2CRY2 | |
| SCHEMBL8282953 | 0.76 | PER2 (0.40) | PER2CRY2 | |
| SCHEMBL13622779 | 0.76 | PER2 (0.40) | PER2CRY2 | |
| SCHEMBL8240286 | 0.75 | PIK3CD (0.63) | PIK3CDPER2CRY2GRM2GRIN1 | |
| SCHEMBL13804489 | 0.72 | PIK3CD (0.59) | PIK3CDPER2CRY2GRM2GRIN1 | |
| SCHEMBL8282897 | 0.72 | PIK3CD (1.00) | PIK3CDPER2CRY2GRM2GRIN1 | |
| SCHEMBL13791864 | 0.71 | PIK3CD (0.62) | PIK3CDPER2CRY2GRM2GRIN1 | |
| SCHEMBL12228958 | 0.70 | PIK3CD (0.59) | PIK3CDPER2CRY2GRM2GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7619094-B2 | Ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus | SCHERING CORPORATION (US) | 2009-11-17 | — | — | US | disclosed |
| US-20070093430-A1 | Novel ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus | MERCK SHARP & DOHME CORP. | 2007-04-26 | — | — | US | disclosed |
| US-7173057-B2 | Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus | SCHERING CORPORATION (US) | 2007-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093430-A1 | Novel ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus | PREP, PRSS1, P4HB | PIK3CD 850/4885PER2 1963/4885CRY2 3659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.